Fueling AI-driven early detection of renal cancer with longitudinal multimodal data

Oncology
Renal Cell Carcinoma
Early Detection
AI Development
Longitudinal Data
Imaging Data
Clinical Data
Pathology Data

Background

Renal cell carcinoma (RCC) is often detected incidentally, and a notable proportion of patients present with stage IV disease at diagnosis when therapeutic options are more limited and prognosis is poorer1.

Earlier identification of RCC remains a major unmet need, with the potential to improve survival and reduce treatment intensity.

AI models are increasingly being developed to analyze abdominal CT imaging and uncover subtle radiologic patterns associated with early-stage RCC, supporting earlier diagnosis and more effective intervention2.

Objective

A top-five global pharmaceutical company contacted Aigora to obtain a regulatory-grade, longitudinal real-world dataset to power AI solutions for early RCC detection.

Delivery

Aigora identified patients across its network with histopathology-confirmed RCC and abdominal CT imaging acquired in the years preceding diagnosis, and assembled a multimodal dataset enriched with comprehensive clinical data and pathology data.

Dataset characteristics

  • Medical imaging

    Longitudinal CT images up to 2 years preceding RCC diagnosis

  • Clinical data

    Clinical data covering over 20 variables, including demographic information, pre-existing health conditions, treatment, medication, outcome, and more

  • Pathology data

    Pathology details corresponding to RCC diagnosis

References

  1. Rose TL, Kim WY. Renal Cell Carcinoma: A Review. JAMA. 2024;332(12):1001-1010. doi:10.1001/jama.2024.12848
  2. Toda N, Hashimoto M, Arita Y, et al. Deep Learning Algorithm for Fully Automated Detection of Small (≤4 cm) Renal Cell Carcinoma in Contrast-Enhanced Computed Tomography Using a Multicenter Database. Invest Radiol. 2022;57(5):327-333. doi:10.1097/RLI.0000000000000842

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Project metrics
  • Number of cases

    100
  • Number of variables per case

    20+
  • Delivery timeline

    8 weeks

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